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目的 探讨新型亚硝脲类抗癌药２氯乙基３肌氨酸酰胺１亚硝脲（ Ｓａｒ Ｃ Ｎ Ｕ） 在动物体内抗人脑胶质瘤的效果。方法 腹腔给 Ｓａｒ Ｃ Ｎ Ｕ 和 Ｂ Ｃ Ｎ Ｕ、 Ｖ Ｍ２６ ，观察位于皮下和颅内移植瘤的生长情况、宿主的体重变化。结果 Ｓａｒ Ｃ Ｎ Ｕ 与对照组相比能明显抑制皮下移植瘤的生长和延长宿主的生存期。结论 Ｓａｒ Ｃ Ｎ Ｕ 比目前临床上常用的 Ｂ Ｃ Ｎ Ｕ 和 Ｖ Ｍ２６ 具有更强的抑制人脑胶质瘤生长的作用。
Objective To investigate the anti-human glioma effect of a novel nitrosoureas anticancer drug 2-chloroethyl- 3 sarcosine amide 1 nitrosourea (Sar C N U) in animals. Methods Sar C N U and B C N U, V M26 were given intraperitoneally to observe the growth of subcutaneous and intracranial transplanted tumors and the weight change of the host. Results Sar C N U significantly inhibited the growth of subcutaneously transplanted tumors and prolonged the survival of the host compared with the control group. Conclusion Sar C N U is more effective than B C N U and V M26, which are commonly used in clinical practice, to inhibit the growth of human gliomas.