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目的:研究血清β-HCG和孕酮对异位妊娠不同保守治疗方法中的预测价值。方法:选择2010年1月~2013年1月在临海市第二人民医院妇产科收治入院符合保守治疗条件的异位妊娠患者作为研究对象。根据治疗方案分为甲、乙两组,并回顾性选取异位妊娠行手术治疗的患者,分为腹腔镜手术和开腹术两组。结果:入组患者150例,甲组和乙组各75例。两组患者的年龄、BMI、孕次、产次、入组时β-h CG、孕酮水平、停经天数、包块大小和两组患者的保守治疗成功率等均无统计学差异(P>0.05);随着血清β-h CG(χ2=63.59,P<0.001)和孕酮(χ2=20.41,P<0.001)水平的升高,保守治疗的成功率有明显下降的趋势;手术组中,腹腔镜术后1天、7天患者β-h CG水平下降速度均显著快于开腹手术患者(P<0.01)。结论:β-h CG和孕酮水平是异位妊娠不同保守治疗方案效果的重要预测因素,且β-h CG下降速度是患者术后恢复速度的重要指标。
Objective: To study the predictive value of serum β-HCG and progesterone in different conservative treatment of ectopic pregnancy. Methods: January 2010 ~ January 2013 in Linhai Second People’s Hospital Obstetrics and Gynecology hospital admission consistent with conservative treatment of ectopic pregnancy patients as the research object. According to the treatment plan is divided into A, B two groups, and retrospectively selected patients undergoing ectopic pregnancy surgery, divided into laparoscopic surgery and laparotomy two groups. Results: 150 patients were enrolled, 75 cases in each of group A and group B. There were no significant differences in age, BMI, gestational age, parity, β-h CG, progesterone level, days of menopause, mass size and conservative treatment success rate between the two groups (P> 0.05). The success rate of conservative treatment decreased significantly with the increase of β-h CG (χ2 = 63.59, P <0.001) and progesterone (χ2 = 20.41, P <0.001) , And the decline rate of β-h CG level was significantly faster in patients undergoing laparoscopic surgery at 1 day and 7 days after laparoscopy (P <0.01). CONCLUSION: β-h CG and progesterone levels are important predictors of the efficacy of different conservative treatment regimens in ectopic pregnancy, and the rate of β-h CG decline is an important indicator of postoperative recovery.