寿尔康对小鼠免疫功能的影响

• 作 者: 李应全 侯琦 马剑峰 种兆忠 盛少虎 袁玮
• 机 构: 山东医科大学药理学教研室,山东医科大学药理学教研室,山东医科大学药理学教研室,山东医科大学药理学教研室,山东医科大学药理学教研室,山东医科大学药理学教研室,
• 出 处: 山东医科大学学报
• 发表日期: 1993年03期
• 关键词: 免疫功能 寿尔康 免疫测定 胞分泌 胸腺重量 免疫学技术 淋巴细胞百分率 杀伤活性 吞噬率 溶血素

应用免疫学技术研究寿尔康(SEK)对小鼠免疫功能的影响。研究发现SEK经口服给药可明显增加小鼠脾脏及胸腺重量,提高小鼠腹腔巨噬细胞的吞噬率和吞噬指数,增加ANAE~+淋巴细胞百分率,促进小鼠外周血溶血素的生成和脾脏抗体细胞分泌溶血素的功能,明显增加小鼠体内NK细胞的活性,使cpm值增大;在体外可提高小鼠NK细胞的杀伤活性;并能增加对小鼠体内YAC-1细胞的清除。提示SEK可增强小鼠特异性和非特异性免疫功能,提高NK细胞的杀伤活性。

Immunological techniques were used to study the effect of SEK on immune function in mice. The study found that oral administration of SEK can significantly increase the weight of spleen and thymus in mice, increase the phagocytosis rate and phagocytic index of mouse peritoneal macrophages, increase the percentage of ANAE~+ lymphocytes, and promote the production of peripheral blood hemolysin and spleen in mice. The function of the antibody cells to secrete hemolysin significantly increased the activity of NK cells in mice, increased the cpm value, increased the killing activity of mouse NK cells in vitro, and increased the clearance of YAC-1 cells in mice. It is suggested that SEK can enhance the specific and non-specific immune function of mice and increase the killing activity of NK cells.