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目的:探讨注射用头孢哌酮/舒巴坦致神经系统不良反应的影响因素,为临床安全用药提供参考。方法:收集我院2011~2012年1 141例应用头孢哌酮/舒巴坦患者中发生神经系统不良反应的病例33例,采用回顾性分析方法对神经系统不良反应的病例的患者基本信息、用药情况、不良反应临床表现等相关因素进行调查分析。结果:33例患者中男22例,女11例;60岁以上患者30例,占90.9%。患者中原患神经内科和肾内科疾病患者27例,占81.8%。33例神经系统不良反应多发生在应用常规剂量头孢哌酮/舒巴坦治疗6~15 d,其次为用药大于15d。33例患者中2例联用左氧氟沙星,1例联用头孢哌酮。神经系统不良反应的临床表现以抽搐、不自主抖动为主,与癫痫症状相似。结论:性别、年龄、基础疾病、给药时间、联合用药等因素对头孢哌酮/舒巴坦致神经系统不良反应可能产生影响。
Objective: To investigate the influencing factors of adverse reactions of cefoperazone / sulbactam in the nervous system for injection, and to provide references for the clinical use of drugs. Methods: Totally 33 cases of nervous system adverse reactions occurred in 1 141 cases of cefoperazone / sulbactam patients in our hospital from 2011 to 2012 were retrospectively analyzed. The basic information and medication of patients with neurological adverse reactions were retrospectively analyzed. Conditions, clinical manifestations and other adverse reactions to investigate and analyze. Results: There were 22 males and 11 females in 33 cases, 30 cases were over 60 years old, accounting for 90.9%. In patients with Central Plains suffering from neurology and renal disease patients in 27 cases, accounting for 81.8%. 33 cases of nervous system adverse reactions occurred in the conventional dose of cefoperazone / sulbactam treatment of 6 to 15 days, followed by medication for more than 15 days. Of the 33 patients, 2 were combined with levofloxacin and 1 was cefoperazone. Clinical manifestations of nervous system adverse reactions to convulsions, mainly involuntary jitter, and symptoms similar to epilepsy. Conclusion: Factors such as gender, age, underlying diseases, administration time and combination therapy may have an impact on the adverse reactions of cefoperazone / sulbactam to the nervous system.