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目的 研究厄多司坦的致突变效应。方法 Am es试验、CHL细胞染色体畸变试验、小鼠骨髓微核试验。结果 在± S9mix条件下 ,每皿厄多司坦的 1.6 7、0 .5 6、0 .19、0 .0 6和 0 .0 2 mg 5个剂量对 TA97、TA98、TA1 0 0 、TA1 0 2 4个菌株无致突变作用 ;在± S9mix条件下的染色体畸变试验中 ,厄多司坦的 2 .49、1.2 5、0 .6 2 5、0 .313mg· m l- 1 4个剂量浓度对 CHL 细胞染色体无致畸变作用 ;以 10、2 .0、0 .4g· kg- 1体重给小鼠灌胃 ,厄多司坦无诱导其骨髓嗜多染红细胞微核增加作用。结论 本试验系统内厄多司坦无致突变作用。
Objective To study the mutagenic effects of erdosteine. Methods Am es test, CHL cell chromosome aberration test, mouse bone marrow micronucleus test. Results At ± S9mix conditions, there was no significant difference in the mean values of TA97, TA98, TA1 0 0, TA1 0 at doses of 1.6 7,0 .5 6,0 .19,0. 0 6 and 0 .0 2 mg for each dish of erdosteine, 24 strains had no mutagenic effect. In the chromosome aberration test under ± S9mix condition, Erdosteine had a dose-response curve of 2.449,1.25,0.62 5,0.313 mg · ml-1 No chromosomal aberrations were induced in CHL cells. The mice were orally gavaged with 10,2. 0,0. 4g · kg-1 body weight. Erdosteine did not induce micronuclei increase in bone marrow polychromatic erythrocytes. Conclusions Endodossin has no mutagenicity in this experimental system.