论文部分内容阅读
Harper 用术语“药物潜伏化”描述前药的原理,后由Kupchan 等修改其定义为:一种生物活性化合物通过化学修饰形成的新化合物,在体内经酶促或非酶促攻击,释出母体化合物而产生药理反应。Von Daehme 等证实,特戊酰氧甲基氨苄青霉素在体内可吸收和迅速重新
Harper used the term “drug latency” to describe the principle of prodrugs and was later modified by Kupchan et al. To define a new compound that is formed by chemical modification of a biologically active compound and releases it in vivo after an enzymatic or non-enzymatic attack Compound and produce pharmacological reactions. Von Daehme et al confirmed that pivaloyloxymethyl ampicillin can be absorbed in the body and quickly re-