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目的研究标准治疗基础上联合氯吡格雷治疗60岁以上急性ST段抬高心肌梗死患者1年疗效及安全性。方法将我院收治的120例60岁以上72h以内发作的急性ST段抬高心肌梗死患者随机分为对照组与观察组,对照组患者行标准基础溶栓治疗,观察组患者在对照组治疗的基础上联合氯吡格雷治疗,随访1年比较两组患者治疗效果以及安全性。结果观察组患者心力衰竭、心绞痛、再发心肌梗死以及脑卒中发生率低于对照组,差异有统计学意义(P<0.05);对照组患者发生轻微血管出血事件4例,观察组发生轻微血管出血事件3例,两组比较差异无统计学意义(P>0.05);两组患者均未发生严重血管出血事件。结论标准治疗基础上联合氯吡格雷治疗60岁以上急性ST段抬高心肌梗死,疗效显著,不良反应小,值得临床推广。
Objective To study the standard treatment of clopidogrel in patients over the age of 60 acute ST-elevation myocardial infarction in patients with 1 year efficacy and safety. Methods A total of 120 patients with acute ST-segment elevation myocardial infarction who were attacked within 72 hours after operation were randomly divided into control group and observation group. Patients in control group received standard-based thrombolytic therapy and patients in observation group were treated in control group Based on the combination of clopidogrel treatment, followed up for 1 year compared the efficacy and safety of two groups of patients. Results The incidence of heart failure, angina pectoris, recurrent myocardial infarction and stroke in the observation group was lower than that in the control group (P <0.05). In the control group, 4 cases of minor vascular haemorrhage occurred and the slight vessel Bleeding events in 3 cases, no significant difference between the two groups (P> 0.05); two groups of patients did not occur serious vascular bleeding. Conclusion Based on the standard treatment combined with clopidogrel in patients over 60 years of acute ST-elevation myocardial infarction, significant effect, adverse reactions, worthy of clinical promotion.