论文部分内容阅读
目的为研究层粘连蛋白与涎腺腺样囊性癌（ＡＣＣ）侵袭和转移的关系。方法用免疫组织化学ＡＢＣ法，观察２５例ＡＣＣ组织中层粘连蛋白（ＬＮ）的表达与分布。结果ＬＮ主要分布在基底膜上以及部分筛状假囊内，腺管内和肿瘤细胞浆内。经统计学检验，发现ＬＮ与病理分型、ＴＮＭ分期和转移有关，即筛状┐管状型、ＴＮＭ早期和无转移者的ＬＮ多阳性表达，而实体型、ＴＮＭ晚期和转移者，ＬＮ多阴性表达。结论ＬＮ表达的高低与ＡＣＣ临床恶性程度侵袭和转移，均有密切关系。
Objective To study the relationship between laminin and invasion and metastasis of salivary adenoid cystic carcinoma (ACC). Methods Immunohistochemical ABC method was used to observe the expression and distribution of laminin (LN) in 25 cases of ACC. Results LN mainly distributed in the basement membrane and part of the sieve pseudocyst, duct and tumor cytoplasm. Statistically, it was found that LN was associated with pathological classification, TNM staging and metastasis, that is, LN with tubular shape, early TNM and no metastasis in TNM. However, LN was negative in solid type, advanced TNM and metastasis, expression. Conclusions The expression of LN is closely related to the invasion and metastasis of clinical malignant degree of ACC.