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人组织激肽释放酶基因6(human tissue kallikreins gene 6,KLK6)是人组织激肽释放酶基因家族的重要成员,是当前研究较热的肿瘤生物学标志物之一,它位于人类19号染色体上,定位于19q13.3-13.4染色体区,编码人类组织激肽释放酶6(hk6)。近年发现hk6广泛存在于人体组织和体液中,在结肠癌、胃癌、食管癌、胰腺癌等消化道肿瘤组织中表达上调,并且KLK6的表达与胃癌的临床分期和淋巴结转移密切相关,可作为一种新的肿瘤标志物,对胃癌的早期诊断和预测预后有一定价值。
Human tissue kallikrein gene 6 (KLK6) is an important member of human tissue kallikrein gene family and one of the hottest tumor biomarkers in the current study. It is located on human chromosome 19 , Located in the 19q13.3-13.4 chromosomal region, encoding human tissue kallikrein 6 (hk6). Recently found that hk6 widely exists in human tissues and body fluids, in colon cancer, gastric cancer, esophageal cancer, pancreatic cancer and other gastrointestinal tumor tissue was upregulated, and KLK6 expression and gastric cancer clinical stage and lymph node metastasis are closely related, can be used as a The new tumor markers, the early diagnosis of gastric cancer and prognosis of a certain value.