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普遍相信心房肽(ANP)在肾排钠的自稳调节中起重要作用,尽管有许多实验支持这种观点,但本文作者认为仍不能充分肯定。事实上,不少收集的实验资料似与其相反的结论更为相符。例如,在正常生理状态下,循环ANP对肾排钠仅有轻微作用。 本文指出,若干年前就已对内源性ANP在心房扩张引起利钠反应中的作用进行过评估,在清醒狗的实验中,二尖瓣部分梗阻使左房压升高,尿量与尿钠增加。与此同时,ANP相应增加约4倍,而
It is generally believed that atrial natriuretic peptide (ANP) plays an important role in the spontaneous regulation of renal allodynia. Although many experiments support this view, the authors believe it still can not be fully affirmed. In fact, many of the experimental data collected seem more consistent with the opposite conclusion. For example, circulating ANP has only a slight effect on renal sodium excretion under normal physiological conditions. This article points out that the role of endogenous ANP in the natriuretic response to atrial dilatation has been evaluated several years ago. In awake dogs, partial mitral regurgitation raises left atrial pressure, urine output and urine Increased sodium. At the same time, ANP increased by about 4 times, while