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全身性红斑狼疮是一种原因不明的、累及许多器官的慢性炎症性疾病。其临床表现呈多样性,包括发热、红斑性皮疹、多发性关节痛、关节炎、多浆膜炎(特别是胸膜和心包)、贫血、血小板减少和肾脏、神经系统及心脏等的病变。红斑狼疮多见于女性,尤其是青春期和青年妇女,其发病率为男性的4倍。由于此病较难发现,其实际发病率可能还要高。自从应用皮质激素等药物以来,暴发性发病和死亡已不多见,大多数表现为慢性经过,发作性活动与长期的完全或几乎完全缓解相交替。此病虽可是轻度而局限于某部位的,但许多病人终因肾、神经系统或其它重要器官的血管受累或因继发性感染而死亡。
Systemic lupus erythematosus is an unexplained chronic inflammatory disease that affects many organs. Its clinical manifestations are diverse, including fever, erythema rash, multiple joint pain, arthritis, polyserositis (especially pleural and pericardial), anemia, thrombocytopenia and kidney, nervous system and heart disease. Lupus erythematosus more common in women, especially adolescent and young women, the incidence of male 4 times. As the disease is more difficult to find, its actual incidence may be even higher. Since the introduction of drugs such as corticosteroids, outbreaks and deaths have been rare, with mostly chronic and seizures alternating with long-term complete or near-complete remission. Although the disease may be mild and confined to a particular site, many patients eventually die of blood vessels in the kidney, nervous system or other vital organs, or from secondary infections.