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肺部肉芽肿病变患者,尤其是肺结节病,其血管紧张素Ⅰ转换酶(ECA)血清活性增加。在过敏性肺病(PH)中通常虽可见到肉芽肿反应,但对该类患者血清ECA活性的测定,有不同的结果。作者观察45例PH病人的血清ECA值,其中农民病肺26例,饲鸟人肺病19例,均经病史,临床,X线和对相关抗原的血清沉淀素检查证实。分为急性型1例,亚急性型12例和慢性型16例。用Treut改进的Cu-shman—Cheung分光光度法测定ECA值。对照组(117例)的正常值为<33u/ml(21.8±5.6u/ml)。急性型PH者ECA值(33.5±5.6u/ml)同对照组相比明显增高(P<0.001),但其血清ECA活性从不超过41u/ml。亚急性型PH者1/12例ECA值高于正常值,但其均值仍高于对照组(26.25±5.7u/ml)。慢性型PH者血清ECA值正常(18±5.4u/ml)。农民肺和
Patients with pulmonary granuloma lesions, especially pulmonary sarcoidosis, have increased serum activity of angiotensin-converting enzyme (ECA). Although Granulomatous reactions are usually seen in Allergic Pulmonary Disease (PH), the determination of serum ECA activity in these patients has different results. The authors observed 45 patients with PH ECV serum values, including 26 cases of peasants lung disease, 19 cases of human bird disease, all confirmed by history, clinical, X-ray and serum antigens on the serum sediment. Divided into acute type in 1 case, subacute type in 12 cases and chronic type in 16 cases. ECT values were determined using Treut modified Cu-shman-Cheung spectrophotometry. The normal control group (117 cases) was <33u / ml (21.8 ± 5.6u / ml). The ECA value of acute type PH (33.5 ± 5.6u / ml) was significantly higher than that of the control group (P <0.001), but its serum ECA activity never exceeded 41u / ml. Subacute type PH 1/12 cases of ECA values higher than normal, but the average is still higher than the control group (26.25 ± 5.7u / ml). Serum ECA values were normal in chronic PH (18 ± 5.4 u / ml). Farmers lungs and