卡那霉素向胚胎耳蜗的移行

• 作 者: 张志超
• 出 处: 国外医学.耳鼻咽喉科学分册
• 发表日期: 1989年06期
• 关键词: 卡那霉素 胎仔 组织学研究 妊娠初期 股静脉 戊巴比妥钠 配糖体 胎盘 二只 螺旋韧带

氨基配糖体类药物通过胎盘向胎仔的耳蜗移行和分布情况的研究尚未见报道。作者给妊娠动物以卡那霉素,对其向胎仔耳蜗移行的情况进行免疫组织学研究。实验分妊娠初期(30～35天)、中期(40～45天)、后期(55～60天)三组,每组各二只豚鼠。在戊巴比妥钠麻醉下,由股静脉缓慢注入卡那霉素(KM)200

Studies on the migration and distribution of amino-glycosylation drugs through the placenta to the cochlea of ​​the fetus have not been reported yet. The authors give kanamycin to pregnant animals and perform immunohistological studies on their migration to the cochlea of ​​the fetus. The experiment was divided into three groups of early pregnancy (30-35 days), mid-term (40-45 days) and late-stage (55-60 days) with two guinea pigs in each group. Kanamycin (KM) 200 was infused slowly from the femoral vein under pentobarbital sodium anesthesia