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目的:研究降纤酶治疗急性脑梗塞的疗效以及对血浆纤维蛋白原的影响。方法:选取2010年4月到2014年6月我院收治的急性脑梗塞患者130例,按照随机数字表法将患者分为研究组和对照组,每组65例,两组均给予常规治疗,对照组在常规治疗的基础上给予安慰剂,研究组给予降纤酶,比较两组临床疗效、神经功能缺损评分、血浆纤维蛋白原水平以及不良反应。结果:研究组总有效率为95.4%,显著高于对照组的76.9%(P<0.05);治疗后研究组神经功能缺损评分与治疗前和对照组比较差异具有统计学意义(P<0.05);治疗后研究组血浆纤维蛋白原显著低于治疗前和对照组(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论:降纤酶治疗急性脑梗塞具有较好的临床疗效,改善患者的神经功能,降低血浆纤维蛋白原。
Objective: To study the therapeutic effect of defibrase on acute cerebral infarction and its effect on plasma fibrinogen. Methods: A total of 130 patients with acute cerebral infarction admitted to our hospital from April 2010 to June 2014 were selected. According to the random number table, the patients were divided into study group and control group, with 65 cases in each group. Both groups were given routine treatment, The control group was given placebo on the basis of routine treatment. The study group was given defibrase. The clinical efficacy, neurological deficit score, plasma fibrinogen level, and adverse reactions were compared between the two groups. Results: The total effective rate was 95.4% in the study group, which was significantly higher than 76.9% in the control group (P <0.05). After treatment, the score of neurological deficit in the study group was significantly different from that before treatment and in the control group (P <0.05) ; After treatment, the plasma fibrinogen in the study group was significantly lower than that before treatment and in the control group (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion: Defibrase in the treatment of acute cerebral infarction has better clinical curative effect, improve the neurological function of patients and lower plasma fibrinogen.