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目的探讨生肌化瘀方95%乙醇提取物对糖尿病小鼠创面愈合的影响。方法采用体内动物试验研究生肌化瘀方95%乙醇提取物(低、中、高浓度)促进糖尿病创面的作用;通过对糖尿病小鼠大体观察,对创面面积、愈合时间、HE染色(肉芽新生、胶原修复、表皮迁移)等数据综合分析了解创面愈合的情况。结果治疗第11天时阳性药组、95%乙醇提取物低剂量组创面面积明显小于模型组(P<0.05);95%乙醇提取部位低浓度创面愈合率高于中、高浓度(P<0.05)。结论生肌化瘀方95%乙醇提取物有明显促进创面愈合的作用。
Objective To investigate the effect of 95% ethanol extract of Shengji Huayu Fang on wound healing in diabetic mice. Methods In vivo animal experiment was used to study the effect of 95% ethanol extract of Shengji Huayu Recipe (low, medium and high concentration) on the wound surface of diabetic rats. The wound area, healing time, HE staining (granulation newborn, Collagen repair, epidermal migration) and other data to understand the situation of wound healing. Results On the 11th day of treatment, the wound area of the low dose of 95% ethanol extract of the positive drug group was significantly smaller than that of the model group (P <0.05). The wound healing rate of low concentration of 95% ethanol extract was higher than that of the medium and high concentration (P <0.05) . Conclusion 95% ethanol extract of Shengji Huayu Recipe can significantly promote wound healing.