论文部分内容阅读
目的:观察门冬氨酸钾镁辅助治疗室性早搏的疗效。方法:室性早搏患者70例随机分为观察组36例和对照组34例。两组均予美托洛尔治疗,观察组同时加用门冬氨酸钾镁辅助治疗,对照组患者同时加用氯化钾缓释片辅助治疗。连续治疗3周后观察两组患者血钾,血清肌酸激酶同工酶、肌酸激酶、乳酸脱氢酶水平和心电图的变化,比较两组疗效和药品不良反应。结果:治疗后两组患者血钾,血清肌酸激酶同工酶、肌酸激酶、乳酸脱氢酶水平均较治疗前改善(P<0.05),且观察组明显优于对照组(P<0.05)。治疗后,两组患者心率及PR间期较治疗前明显改善(P<0.05),而治疗后两组间差异无统计学意义(P>0.05)。观察组总有效率为91.67%,高于对照组的82.35%(P<0.05)。观察组药品不良反应发生率明显低于对照组(P<0.05)。结论:门冬氨酸钾镁辅助治疗室性早搏,能明显改善患者血钾和血清心肌酶水平,改善患者心率和心电图,疗效与药品不良反应均优于氯化钾缓释片辅助治疗。
Objective: To observe the effect of potassium-magnesium aspartate adjuvant treatment of ventricular premature beats. Methods: 70 cases of premature ventricular contractions were randomly divided into observation group 36 cases and control group 34 cases. Both groups were treated with metoprolol, while the observation group plus potassium-magnesium aspartate adjuvant therapy, while patients in the control group were supplemented with potassium chloride sustained-release tablets adjuvant therapy. After 3 weeks of continuous treatment, changes of serum potassium, serum creatine kinase, creatine kinase, lactate dehydrogenase and electrocardiogram were observed. The curative effect and adverse drug reactions were compared between the two groups. Results: After treatment, serum potassium, serum creatine kinase, creatine kinase and lactate dehydrogenase were both improved (P <0.05), and the observation group was significantly better than the control group (P <0.05 ). After treatment, heart rate and PR interval were significantly improved in both groups (P <0.05), but there was no significant difference between the two groups after treatment (P> 0.05). The total effective rate in the observation group was 91.67%, which was higher than that in the control group (82.35%, P <0.05). The incidence of adverse drug reactions in the observation group was significantly lower than that in the control group (P <0.05). CONCLUSION: Potassium and magnesium aspartate adjuvant therapy for ventricular premature beats can significantly improve the levels of serum potassium and serum myocardial enzymes and improve the heart rate and electrocardiogram of patients. The curative effect and adverse drug reactions are superior to those of potassium chloride sustained-release tablets.