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目的:制备姜黄素(Cur)固体脂质纳米粒(SLN)。方法:用薄膜超声法制备Cur-SLN,以mcur:m单硬脂酸甘油酯、m单硬脂酸甘油酯:m卵磷脂、聚山梨酯-80质量浓度、超声时间为考察因素,以包封率为指标,用正交试验优选处方,并考察其粒径分布、Zeta电位。结果:当mcur:m单硬脂酸甘油酯=1:3、m单硬脂酸甘油酯:m卵磷脂=1:2.5、聚山梨酯-80质量浓度2.5%、超声时间12min时,所制得的Cur-SLN平均粒径为(145.6±5)nm,Zeta电位为(-31.9±1.5)mV,包封率为(97.42±0.39)%,载药量为(7.92±0.05)%。结论:采用薄膜-超声法制备Cur-SLN可行,为开发姜黄素新型给药系统提供试验依据。
Objective: To prepare Cur solid lipid nanoparticles (SLN). Methods: Cur-SLN was prepared by thin-film ultrasonic method. The effects of mcur: m glyceryl monostearate, m-glyceryl monostearate: m lecithin, polysorbate 80 and ultrasonic time were investigated. Occlusion rate as an indicator, using orthogonal test prescription, and study its particle size distribution, Zeta potential. Results: When mcur: m glyceryl monostearate = 1: 3, m glycerol monostearate: m lecithin = 1: 2.5, polysorbate 80 at 2.5% The average particle size of Cur-SLN was (145.6 ± 5) nm and the Zeta potential was (-31.9 ± 1.5) mV. The encapsulation efficiency was (97.42 ± 0.39)% and drug loading was (7.92 ± 0.05)%. Conclusion: It is feasible to prepare Cur-SLN by thin-film-ultrasonic method and provide experimental basis for the development of new curcumin delivery system.