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１型人类免疫缺陷症病毒（ＨＩＶ－１）ＤＮＡ疫苗能诱导实验动物产生体液和细胞免疫应答，但这些免疫应答弱且短暂。ＤＮＡ疫苗免疫研究结果证实，白细胞介素２（ＩＬ－２）或粒细胞巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）基因与ＨＩＶ－１基因共表达可增强抗原特异性抗体应答
Human immunodeficiency virus type 1 (HIV-1) DNA vaccines induce humoral and cellular immune responses in experimental animals, but these immune responses are weak and transient. DNA vaccine immunization results confirmed that co-expression of interleukin 2 (IL-2) or granulocyte-macrophage colony-stimulating factor (GM-CSF) gene with HIV-1 gene enhances antigen-specific antibody response