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目的:分析抗磷脂综合征(APS)血管病变的临床特点。方法:回顾分析16例APS血管病变的住院患者,所有患者均有完整的病历资料。结果:外周血管病变6例,脑梗死3例,心肌梗死2例,双侧肾动脉受累1例,左侧肾动脉受累1例,门静脉受累1例,肝动脉1例,肠系膜下动脉1例。抗心磷脂抗体(aCL)阳性13例,狼疮抗凝物(LA)阳性9例,aCL和LA同时阳性6例。5例外周血管病变患者行彩色多普勒诊断仪检查,4例表现为血栓形成、3例血管狭窄。15例行血管造影,表现为不同程度的血栓形成和血管狭窄、2例内膜或(和)外膜增厚。全部患者给予给予规范化治疗,预后良好。结论:抗磷脂综合征可以累及大小不同的血管,表现为血栓形成和(或)血管狭窄,经积极治疗一般预后良好。
Objective: To analyze the clinical features of anti-phospholipid syndrome (APS) vascular lesions. Methods: A retrospective analysis of 16 patients with APS vascular disease inpatients, all patients have a complete medical records. Results: There were 6 cases of peripheral vascular disease, 3 cases of cerebral infarction, 2 cases of myocardial infarction, 1 case of bilateral renal artery involvement, 1 case of left renal artery involvement, 1 portal vein involvement, 1 hepatic artery and 1 inferior mesenteric artery. 13 were positive for anticardiolipin antibodies (aCL), 9 were positive for lupus anticoagulant (LA), and 6 were positive for both aCL and LA. Five patients with peripheral vascular disease underwent color Doppler diagnostic examination, 4 cases showed thrombosis, 3 cases of vascular stenosis. 15 cases of angiography, showed varying degrees of thrombosis and vascular stenosis, 2 cases of intima or (and) the outer membrane thickening. All patients given to give standardized treatment, the prognosis is good. CONCLUSIONS: Antiphospholipid syndrome can affect blood vessels of different sizes, showing thrombosis and / or vascular stenosis, and generally have a good prognosis after active treatment.