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研究肝硬化患者的门体分流与性激素的关系。采用９９ｍＴｃ─ＭＩＢＩ（甲氧基异晴）测定心／肝放射性摄取比值（Ｈ／Ｌ比值）作为门体分流指标。２０例男性肝硬化患者的雌二醇（Ｅ２）及催乳素（ＰＲＬ）水平明显高于正常对照组（Ｐ＜０．０１），睾酮（Ｔ）及黄体生成素（ＬＨ）明显低于正常对照组（Ｐ＜０．０１），而卵泡刺激素（ＦＳＨ）水平无明显改变（Ｐ＞０．０５）。与正常人群相比，肝硬化患者的Ｈ／Ｌ值明显增高（Ｐ＜０．０１），且与Ｅ２水平有明确的正相关（（ｒ＝０．７８，Ｐ＜０．０１）与ＬＨ有明确的负相关（ｒ＝０．６２，Ｐ＜０．０５），而与其他激素（ＦＳＨ，Ｔ及ＰＲＬ）无明确相关。５种激素与肝细胞功能指标（血清白蛋白、凝血酶原时间、总胆红素）无明确相关。肝硬化时肝细胞功能的损伤可能不是致性激素紊乱的主要原因，而肝硬化时的门体分流可能在引起性激素变化中起着重要的作用。
To study the relationship between portal shunt and sex hormones in cirrhotic patients. Cardiac / hepatic radioactivity uptake ratio (H / L ratio) was measured using99mTc-MIBI (methoxyisochloroi) as a portosystemic shunt index. The levels of estradiol (E2) and prolactin (PRL) in 20 patients with cirrhosis were significantly higher than those in the normal control group (P <0.01), and the levels of testosterone (T) and luteinizing hormone (P <0.01), while the level of follicle stimulating hormone (FSH) had no significant change (P> 0.05). Compared with the normal population, the H / L of patients with cirrhosis was significantly higher (P <0.01), and there was a clear positive correlation with E2 (r = 0.78, P <0.01) (R = 0.62, P <0.05), but not with other hormones (FSH, T and PRL) .5 hormones and hepatocyte function indexes (serum albumin, prothrombin time , Total bilirubin.) Liver cell function impairment during cirrhosis may not be the main cause of sex hormone disturbances, whereas portal shunting during cirrhosis may play an important role in causing changes in sex hormones.