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糖尿病神经病变是糖尿病常见并发症,其发病机理迄今尚未完全阐明。大量的临床和实验研究显示代谢异常及血管损害对糖尿病神经病变的发生具有重要作用。近年来,对血管机理的研究有一定的进展,尤其随着内皮源性舒张因子一氧化氮的发现及人们对其逐步深入的研究,使糖尿病神经病变的血管机理及其与代谢因素的联系又有了新的发现,对糖尿病神经病变病因的解释及其治疗方面产生了积极作用。 1 一氧化氮(NO)的一般生物学特征 NO的研究始于1980年内皮源性舒张因子(Endothelium-derived releasing factor,EDRF)的提出,当时发现内皮细胞上的乙酰胆碱能诱导兔
Diabetic neuropathy is a common complication of diabetes, the pathogenesis has not yet been fully elucidated. A large number of clinical and experimental studies have shown that metabolic abnormalities and vascular damage play an important role in the pathogenesis of diabetic neuropathy. In recent years, there has been some progress in the study of the vascular mechanism. Especially with the discovery of endothelium-derived relaxing factor nitric oxide and its in-depth study, the vascular mechanism of diabetic neuropathy and its relationship with metabolic factors With the new findings, it has played an active role in explaining the etiology of diabetic neuropathy and its treatment. 1 General biological characteristics of nitric oxide (NO) The study of NO started from the endothelium-derived releasing factor (EDRF) in 1980. At that time, it was found that acetylcholine on endothelial cells induced rabbit