3-58 Telomerase Activity Inhibition Block DNA Damage Repair

• 作 者: Sun Chao Wang Yali Zhang Hong
• 机 构: 不详
• 出 处: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 发表日期: 2014年1期
• 关键词: TELOMERASE ACTIVITY INHIBITION
• 基金项目: Key Program of National Natural Science Foundation of China (U1432248), Western Talent Program of ChineseAcademy of Sciences (Y460040XB0), National Natural Science Foundation of China (11175222).

Previous studies in malignant cells have shown that irradiation-induced upregulation of telomerase activity,not only protected damaged telomeres, but also contributed to DNA damage repair by chromosomal healing andincreased resistance to irradiation[1;2].