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目的观察间苯三酚联合卡孕栓用于人工流产的效果。方法选择2011年3月—2012年11月要求终止妊娠的妇女317例,随机分为A组106例、B组107例、C组104例。A组:在人工流产术前30 min消毒阴道后将卡孕栓0.5 mg置于阴道后穹隆部,术前15 min肌内注射间苯三酚40 mg;B组:单用间苯三酚,术前15 min肌内注射40mg;C组:单用卡孕栓,方法同A组。三组患者均在设定时间内行人工流产术。术中观察患者宫颈松弛情况、镇痛效果、出血量以及人工流产综合征发生情况。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果 A组无阻力扩宫71.70%,B组67.29%,C组66.35%,A组无阻力扩宫率与B组、C组比较差异均无统计学意义(χ2=0.488、0.704,均P>0.05)。术中出血量A组(10.31±7.76)ml、B组(12.14±7.78)ml、C组(11.28±8.52)ml,A组术中出血量与B组、C组比较差异均无统计学意义(t=1.719、0.863,均P>0.05)。仅B组发生人工流产综合征1例。镇痛总有效率A组92.45%、B组57.94%、C组50.96%,A组与B组、C组比较差异均有统计学意义(χ2=33.926、44.735,均P<0.05)。结论间苯三酚和卡孕栓联合应用于人工流产可从不同方面起到镇痛作用,可最大限度地减轻手术带来的疼痛,增加了手术的安全性。
Objective To observe the effect of phloroglucinol combined with carbamazole on induced abortion. Methods A total of 317 women requesting termination of pregnancy from March 2011 to November 2012 were randomly divided into group A (n = 106), group B (n = 107) and group C (n = 104). Group A: 0.5 mg carbacarb suppository was placed in the posterior vaginal vault after disinfecting the vagina 30 min prior to abortion; intraocular injection of 40 mg phloroglucinol was given 15 min before operation; Group B: phloroglucinol alone, 15 min before intramuscular injection of 40mg; C: single card pregnant pregnancy suppository, the same method with the A group. Three groups of patients were set within the time of artificial abortion. Intraoperative observation of patients with cervical relaxation, analgesic effect, the amount of bleeding and the incidence of induced abortion syndrome. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The resistance-free expansion in group A was 71.70%, in group B 67.29% and in group C 66.35%. There was no significant difference between group A and group B and group C (χ2 = 0.488, 0.704, P < 0.05). The blood loss in group A was (10.31 ± 7.76) ml, in group B (12.14 ± 7.78) ml and in group C (11.28 ± 8.52) ml respectively. There was no significant difference in the intraoperative blood loss between group A and group B and group C (t = 1.719,0.863, all P> 0.05). Only one case of abortion syndrome occurred in group B. The total effective rate of analgesia was 92.45% in group A, 57.94% in group B and 50.96% in group C, there were significant differences between group A and group B and group C (χ2 = 33.926 and 44.735, all P <0.05). Conclusion The combination of phloroglucinol and carbamazepine in abortion can play an analgesic effect in different aspects, which can minimize the pain caused by surgery and increase the safety of operation.