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目的:探讨巨噬细胞集落刺激因子(M-CSF)在骨巨细胞瘤中的表达与肿瘤病理学分级及生物学行为的相关性。方法:对58例骨巨细胞瘤进行Jaffe分级;采用组织学方法观察出血坏死、侵袭血管或周围组织,病例随访6月-6年确认是否复发;免疫组化SP法检测M-CSF在骨巨细胞瘤中的表达,半定量分析它们与肿瘤病理Jaffe分级及生物学行为之间的相关性。结果:Jaffe分级与肿瘤生物学行为无明显相关性;M-CSF表达与肿瘤的出血坏死、侵袭存在一定的相关性,而与肿瘤的复发无明显相关性;M-CSF表达强度与病理Jaffe分级呈负性相关关系。结论:通过检测骨巨细胞瘤中M-CSF的表达,可以协助进行肿瘤病理Jaffe分级,推断肿瘤的生物学行为并判断预后。
Objective: To investigate the relationship between the expression of macrophage colony-stimulating factor (M-CSF) in giant cell tumor of bone and the pathological grade and biological behavior of the tumor. Methods: Fifty-eight cases of giant cell tumor of bone were treated with Jaffe classification. Hemorrhagic necrosis and invasion of blood vessels or surrounding tissues were observed by histology. The cases were followed up for 6 months to 6 years to confirm recurrence. Immunohistochemical SP method was used to detect the expression of M-CSF in bone giant Cell tumor, semi-quantitative analysis of their relationship with tumor pathological Jaffe classification and biological behavior. Results: There was no significant correlation between Jaffe classification and tumor biological behavior. The expression of M-CSF had some correlation with hemorrhage, necrosis and invasion of tumor, but had no correlation with tumor recurrence. The expression of M-CSF and pathological Jaffe classification Negative correlation. Conclusion: By detecting the expression of M-CSF in giant cell tumor of bone, we can assist in the classification of tumor by pathological Jaffe, infer the biological behavior of the tumor and judge the prognosis.