Correlation of expression of STAT3, VEGF and differentiation of Th17 cells in psoriasis vulgaris of

• 作 者: Xiu-Fen Zheng Yue-Dong Sun Xue-Yan Liu
• 机 构: Department of Dermatology, South Hospital, Southern Medical University, Guangzhou 510000, China“,”De
• 出 处: 亚太热带医药杂志（英文版）
• 发表日期: 2014年4期
• 关键词: Psoriasis T help 17 cells STAT3-VEGF pathway

Objective: To investigate the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis. Methods: A total of 50 cases of psoriasis guinea pigs and 20 normal guinea pigs were selected. The ratio of Th17/ IL-17 cell in peripheral blood were detected by flow cytometric analysis; STAT3 and VEGF concentrations were measured by immunohistochemistry and West blot. Results: The expression of Th17 in peripheral blood were significantly increased in psoriasis [(1.76±0.88)%] compared with controls [(0.48±0.27)%] (P<0.05). Th17 related cytokine STAT3 and VEGF were significantly increased in psoriasis compared with controls (P<0.05), and were positively correlated the expression of Th17. Conclusions: The expressions of Th17, STAT3 and VEGF are elevated in psoriasis, which suggests Th17 cells have a potential role in the pathogenesis of psoriasis by STAT3-VEGF pathway.