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目的 探讨慢性充血性心力衰竭 (CHF)患者血清中CA12 5和肿瘤坏死因子α(TNFα)的浓度与心功能和心脏扩大的关系。方法 10 2例心力衰竭患者根据纽约心脏病学会心功能分级标准分为心功能Ⅱ～Ⅳ级组 ,根据超声心动图检查结果分为左室常大组 (左室舒张末期容积≤ 5 5mm)和左室扩大组 (左室舒张末期容积 >5 5mm)。用酶联免疫吸附测定法测定CA12 5和TNFα的血清浓度。并选 2 0名正常人作为对照。结果 CHF患者CA12 5和TNFα的浓度明显高于正常对照组 (P<0 .0 5 ～ 0 .0 1) ,心功能Ⅲ、Ⅳ级的血清浓度高于Ⅱ级 (P <0 .0 1)。左室扩大组较左室常大组CA12 5和TNFα的血清浓度显著升高 (P <0 .0 1) ,CA12 5和TNFα的血清浓度与心力衰竭患者的心脏扩大呈正相关 (r=0 .6 2 1及 0 .5 4,P <0 .0 5 )。结论 CHF患者血清中CA12 5和TNFα的血清浓度升高 ,升高水平与CHF患者心脏扩大呈正相关。
Objective To investigate the relationship between serum CA12 5 and tumor necrosis factor α (TNFα) in patients with chronic congestive heart failure (CHF) and their cardiac function and cardiac enlargement. Methods Twenty-two patients with heart failure were divided into two groups according to the New York Heart Association grading criteria: group Ⅱ ~ Ⅳ. According to the results of echocardiography, they were divided into two groups: left ventricular hypertrophy group (left ventricular end-diastolic volume ≤ 5 5 mm) Left ventricular enlargement group (left ventricular end-diastolic volume> 5 5mm). Serum concentrations of CA12 5 and TNFα were determined by enzyme-linked immunosorbent assay. And select 20 normal people as a control. Results The serum levels of CA12 5 and TNFα in CHF patients were significantly higher than those in normal controls (P <0.05-0.01). The serum levels of cardiac function Ⅲ and Ⅳ were higher than those in patients with grade Ⅱ (P0.01) . The serum concentrations of CA12 5 and TNFα in patients with left ventricular enlargement were significantly higher than those in patients with chronic left ventricular enlargement (P0.01). The serum concentrations of CA12 5 and TNFα were positively correlated with the enlargement of heart in patients with heart failure (r = 0. 6 2 1 and 0 .5 4, P <0. 05). Conclusions Serum levels of CA12 5 and TNFα in CHF patients are elevated. The elevated level is positively correlated with the enlargement of heart in CHF patients.