7β-羟基胆固醇双琥珀酸单酯钠(RS034)含量的测定方法研究(Ⅲ)——改良Abell法

• 作 者: 齐美玲 陈仁弟 孙嘉奎 赵瑞亭 黄艳
• 机 构: 沈阳药学院药物分析教研室,沈阳药学院药物分析教研室,沈阳药学院药物分析教研室,沈阳药学院药物分析教研室,沈阳药学院药物分析教研室
• 出 处: 沈阳药学院学报
• 发表日期: 1989年02期
• 关键词: 琥珀酸单酯钠 Abell RS034 试剂法 含量测定 抗癌活性物质 测定方法研究 冰醋酸溶液 原料药 文献报道

RS034是一种新型抗癌活性物质,化学名为7—β—羟基胆固醇双琥珀酸单酯钠(SodiumSalt of bishemisuccinate of 7-β-hydroxycholesterol)。它的测定方法尚未见文献报道。陈仁弟等曾根据其母核——胆固醇的含量测定方法,对原料药RS034的含量测定进行过研究。在此基础上,本文又提出了一种新的含量测定方法——改良Abell法。测定结果经F检验和t检验证明,本法与单一试剂法无显著差异。

RS034 is a novel anticancer active substance, chemically named Sodium Salt of Bishemisuccinate of 7-β-hydroxycholesterol. Its measurement method has not been reported in the literature. Chen Rendi and others had studied the determination of the drug substance RS034 according to its parent nuclear cholesterol measurement method. On this basis, this paper also proposes a new method for the determination of content - the modified Abell method. The results of the test were confirmed by F-test and t-test. There was no significant difference between this method and the single-agent method.