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一项新的研究结果显示,用以治疗高血压和心血管疾病的噻嗪类利尿药物有可能增加胆囊炎的发病风险。现有证据表明,使用噻嗪类药物治疗可增加患者胆汁中的胆固醇的饱和度,但评估该药物与胆囊疾病的关联性研究常会出现复杂性结果。来自于美国马里兰州国家癌症研究所的 Michael F.Leitzmann博士及其同事自1980年以来对近81000名参加美国护士健康研究项目的年龄范围为30～55岁的妇女进行了为期20年的随访调查;并在近期出版的《内科学年鉴》(AIM)杂志上刊文指出,为期20年的随访调查结果显示,
A new study shows that thiazide diuretics used to treat high blood pressure and cardiovascular disease may increase the risk of cholecystitis. Available evidence suggests that the use of thiazide therapy may increase the patient’s cholesterol saturation in the bile, but the study of the drug’s association with gallbladder disease often presents complex results. Dr. Michael F. Leitzmann from the National Cancer Institute in Maryland, Maryland, and colleagues have conducted a 20-year follow-up survey of nearly 81,000 women aged 30-55 years who participated in the American Nurses’ Health Research Program since 1980 ; And recently published in the “Annals of Internal Medicine” (AIM) magazine pointed out that the follow-up survey of 20 years showed that,