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处理由皮肤真菌引起的甲癣,在皮肤病学中是最困难的治疗问题之一。已报道了一个新的局部用药治疗甲癣的方法,配方是在含有22%十一烯酸和50%乙酸乙酯的液体基质中加入28%的康唑(ti-oconazole)。22%病人取得临床痊愈,真菌学检查阴性,更多的病人获明显进步,但不能完全根除大多数受累的甲感染。因此作者试图外用此配方结合口服灰黄霉素来治疗甲癣,并评价其效果。作者选择了10例患者(6男、4女),24～64岁(平均56岁),共70个左右对称的趾甲,全部为红色毛癣菌感染。参加研究的病人予500mg 灰黄霉素口服,每日2次;每一病人一侧黄甲用含28%的康唑的外用药,另一侧只用基质,一天涂2次。外用
Treating onychomycosis caused by dermatophytes is one of the most difficult treatment problems in dermatology. A new method of topical treatment of onychomycosis has been reported by adding 28% ti-oconazole to a liquid matrix containing 22% undecylenic acid and 50% ethyl acetate. 22% of patients achieved clinical recovery, mycology negative, more patients have been significantly improved, but can not completely eradicate the majority of affected A infection. Therefore, the authors attempted to topically apply this formula in combination with oral griseofulvin to treat onychomycosis and evaluate its efficacy. The authors selected 10 patients (6 males and 4 females) and 24 to 64 years (mean 56 years) with about 70 symmetrical nails, all of which were infected with Trichophyton rubrum. Participants were given 500 mg of griseofulvin orally twice daily; each patient was given a topical application of 28% conazole on one side and only twice a day on the other side. external use