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目的:探讨参与雌激素分解代谢的儿茶酚-O-甲基转移酶(catachol-O-methyltransferase,COMT)的基因多态性与子宫内膜增生发生风险的关系。方法:以多聚酶链反应-限制性片段长度多态性法对100例子宫内膜增生患者和110例对照者的COMT基因第4外显子第158位密码子G/A的多态性进行分析,用非条件logistic回归分析COMT基因多态性与子宫内膜增生的遗传易感性的关系。结果:两组的COMT基因型分布频率无统计学差异(P>0.05),皆以COMTVal/Val基因型为主(47.3%)。经Logic回归分析,与COMTMet/Met基因型相比,COMTVal/Val基因型的优势比(OR)=0.988(95%CI=0.137-7.116),COMTVal/Met基因型的OR值=0.656(95%CI=0.094-4.582)。结论:COMT基因多态性与中国南方女性子宫内膜增生过长发生风险无相关性,COMTMet/Met基因型不增加患子宫内膜增生的风险。
Objective: To investigate the relationship between the gene polymorphisms of catechol-O-methyltransferase (COMT) involved in estrogen catabolism and the risk of endometrial hyperplasia. Methods: Polymorphism of G / A at codon 158 of exon 4 of COMT gene in 100 patients with endometrial hyperplasia and 110 controls was analyzed by polymerase chain reaction-restriction fragment length polymorphism , Non-conditional logistic regression analysis of COMT gene polymorphisms and genetic susceptibility to endometrial hyperplasia. Results: There was no significant difference in the frequency of COMT genotype distribution between the two groups (P> 0.05), and the COMTVal / Val genotype was predominant (47.3%). According to the logistic regression analysis, the odds ratio (OR) of the COMTVal / Val genotype was 0.988 (95% CI = 0.137-7.116) and that of the COMTVal / Met genotype was 0.656 (95% CI = 0.094-4.582). Conclusion: There is no correlation between the COMT gene polymorphism and the risk of endometrial hyperplasia in southern China. The COMTMet / Met genotype does not increase the risk of endometrial hyperplasia.