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水盐代谢激素的变化在肝硬化腹水发生机制中具有重要作用。本文观察了肝硬化腹水病人血浆肾素活性—血管紧张素—醛固酮系统（RAAS）、肾前列腺素（PGs）的代谢变化及其与肾功能的关系。材料与方法：将研究对象分为三组：肝硬化失代偿病人伴腹水27例（DC）组，肝硬化代偿病人17例（CC）组，正常人16例（NC）组。采用放免法测定血浆肾素活性（PRA）、血管紧张素I（AI）、醛固酮（ALD）、尿PGE_2、6-keto-PGF_(1α)、TXB_2。肾有效血浆流量（ERPF）按Tauxe方法，用指数曲线拟合公式计算。内生肌酐清除率（Cc_1）及24小时尿钠定量（UNaV/24h）按本院常规方法测定。
Changes in water and salt metabolism hormones play an important role in the pathogenesis of cirrhosis and ascites. This article investigates the metabolic changes of plasma renin activity - angiotensin-aldosterone system (RAAS) and prostaglandin (PGs) in cirrhotic patients and its relationship with renal function. MATERIALS AND METHODS: The subjects were divided into three groups: 27 patients with decompensated cirrhosis with ascites (DC), 17 patients with compensated cirrhosis (CC) and 16 normal subjects (NC). Plasma renin activity (PRA), angiotensin I (AI), aldosterone (ALD), urinary PGE 2, 6-keto-PGF_ (1α) and TXB_2 were measured by radioimmunoassay. Renal Effective Plasma Flow (ERPF) was calculated using the exponential curve fitting method by the Tauxe method. Endogenous creatinine clearance (Cc_1) and 24-hour urinary sodium quantification (UNaV / 24h) were determined by routine methods in our hospital.