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目的:系统评价唐氏综合征产前筛查策略的经济性。方法:检索与唐氏综合征产前筛查经济学评价相关的文献,对纳入文章进行质量评价,运用描述性方法系统评价筛查策略的经济性。结果:根据纳入和排除的标准,共纳入15篇文献。纳入文献经质量评价、描述性分析对文献的基本信息、评价方法、评价结果进行系统总结。结论:从社会成本的角度,对孕妇进行DS筛查是具有成本效果的医疗保健措施,将年龄筛查、超声筛查和血清学筛查针对孕期综合筛查策略有较大的优势,其中对筛查的成本效果较好。
Objective: To systematically evaluate the economics of prenatal screening strategies for Down Syndrome. Methods: The literature related to the prenatal screening economic evaluation of Down Syndrome was searched, the quality of the included articles was evaluated, and the descriptive method was used to evaluate the economic efficiency of screening strategies. Results: Based on the inclusion and exclusion criteria, a total of 15 articles were included. Literature included in the quality evaluation, descriptive analysis of the basic information of the literature, evaluation methods, evaluation results were systematically summarized. Conclusion: DS screening of pregnant women is a cost-effective health care measure from the perspective of social cost. Age screening, ultrasound screening and serological screening have great advantages for comprehensive pregnancy screening screening strategy. The cost of screening is better.