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目的 :探讨血浆D 二聚体 (D dimer,DD)与冠心病(CHD)病情及冠状动脉病变稳定性的关系。方法 :对 1 1 0例观察对象按照冠状动脉造影病变形态学特征分为 :简单病变组 3 2例 ,复杂病变组 5 6例 ,正常对照组 2 2例。同时 ,根据临床CHD病情分为 :急性心肌梗死 (AMI)组 1 1例、不稳定型心绞痛 (UAP)组 49例 ,稳定型心绞痛(SAP)组 2 8例 ,正常对照组 2 2例。用酶免法 (ELASA)检测血浆DD含量 ,比较不同组间DD含量。结果 :血浆DD含量复杂病变组 [( 0 .499± 0 .2 1 4)mg/L]高于简单病变组 [( 0 .3 2 9± 0 .1 73 )mg/L]及正常对照组 [( 0 .3 1 9± 0 .1 2 6)mg/L],差异均有统计学意义 (P <0 .0 1 )。AMI组 [( 0 .5 93± 0 .3 44 )mg/L]和UAP组 [( 0 .471± 0 .2 1 4)mg/L]明显高于SAP组 [( 0 .2 92±0 .1 0 1 )mg/L]及正常对照组 [( 0 .3 1 9± 0 .1 2 6)mg/L],差异均有统计学意义 (P <0 .0 1 )。结论 :血浆DD含量与冠状动脉病变稳定性及CHD病情严重性相关 ,DD是冠状动脉病变活动性的血液标志物。
Objective: To investigate the relationship between plasma D dimer (DD) and coronary heart disease (CHD) and the stability of coronary artery disease. Methods: One hundred and ten patients were divided into three groups: simple lesions group (n = 32), complicated lesions group (n = 56) and normal control group (n = 22) according to the morphological features of coronary angiography. At the same time, according to the clinical CHD condition, 11 cases were divided into AMI group, 49 cases of unstable angina pectoris group, 28 cases of SAP group and 22 cases of normal control group. Plasma enzyme-linked immunosorbent assay (ELASA) was used to detect the level of DD in plasma. Results: The plasma levels of DD in patients with complex lesions were significantly higher than those in patients with simple lesions ((0.392 ± 0.144) mg / L and [(0.31 9 ± 0.126) mg / L], the differences were statistically significant (P <0.01). (0.493 ± 0.344 mg / L) and UAP group [(0.47 ± 0.244 mg / L)] were significantly higher than those in SAP group [(0.2292 ± 0 .1 0 1) mg / L] and normal control group [(0.31 9 ± 0.126) mg / L], the differences were statistically significant (P <0.01). Conclusion: The plasma DD level is related to the stability of coronary artery disease and the severity of CHD. DD is a blood marker of coronary artery lesion activity.