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1960年Nowoll和Hungerford氏在慢性粒细胞型白血病(简称慢粒)中发现一个共同的异染色体,以其发现地点PhiladelPhia命名(简称Ph~1)。近年来由于分带技术的应用,进一步发现了不少新的现象,现就其相关的几个问题讨论如下: 一、Ph~1染色体的起源与特征在慢粒中,约有85—90％的病例可见到Ph~1染色体的存在,与种族及性别无关。目前已将Ph~1的存在与否作为诊断慢粒的一个重要指标。关于Ph~1染色体的来源,最初认为是G组4个染色体之一有缺失。1971年CasPersson氏等应用Q—分带明确Ph~1染色体不是21号而是22号染色体。1973年Rowley氏应用Q—,G—及R—带技术在9例慢粒骨髓细胞中,发现9号染色
In 1960, Nowoll and Hungerford’s found a common heterochromosome in chronic myeloid leukemia (hereinafter referred to as Philadelphi) named Phyl 1 for its discovery. In recent years, due to the application of the zoning technology, we have found many new phenomena. We discuss the following several issues related to them: 1. The origin and characteristics of the Ph ~ 1 chromosome In the CML, about 85-90% Of cases can be seen Ph ~ 1 chromosome exists, regardless of race and gender. The presence or absence of Ph ~ 1 has now been used as an important indicator in the diagnosis of CML. The origin of the Ph ~ 1 chromosome was originally thought to be missing in one of the four G chromosomes. In 1971 CasPersson et al. Used Q-banding to clarify that chromosome Ph ~ 1 was not chromosome 21 but chromosome 22. Rowley’s 1973 Q-, G-, and R-band techniques were used in 9 patients with slow-bone marrow cells and found that No. 9 staining