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目的研究nm23基因在大肠癌组织中的表达及临床意义。方法用免疫组化方法对63例大肠癌患者骨髓内转移癌细胞及肿瘤组织内nm23表达进行了测定。结果骨髓内转移癌细胞阳性者原发灶nm23蛋白表达率53．1％，低于骨髓内转移癌细胞阴性者的表达率77．4％，有统计学差别（P＜0．05）。发生肝、肾及腹腔广泛转移者原发灶表达率50．0％，低于未发生转移者的表达率81．8％（P＜0．05）。nm23蛋白表达与淋巴结转移无显著相关性。结论nm23蛋白表达与远处转移及骨髓内转移癌细胞呈负相关性，可作为预测转移和判断预后的标志物。
Objective To study the expression and clinical significance of nm23 gene in colorectal cancer. Methods Immunohistochemistry was used to determine the expression of nm23 in metastatic cancer cells and tumor tissues of 63 patients with colorectal cancer. Results The expression rate of nm23 protein in the primary tumor metastasis-positive in bone marrow was 53.1%, which was lower than that in the negative bone marrow metastasis cancer-negative patients (77.4%). There was significant difference (P<0.05). The expression rate of primary lesions in liver, kidney, and peritoneal metastasis was 50.0%, which was lower than that of non-metastasis (81.8%) (P<0.05). There was no significant correlation between nm23 protein expression and lymph node metastasis. Conclusion The expression of nm23 protein is negatively correlated with distant metastasis and metastasis of cancer cells in bone marrow. It can be used as a marker to predict metastasis and determine prognosis.