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苯甲醇对早产的新生儿有致命的危险。据美国FDA1982年5月28日给医院药师的一封信中称:共有16名新生儿(体重均在2500g 以下)因用了含0.9%苯甲醇的生理盐水冲洗过的血管插管,或是接受了用含苯甲醇的制菌注射用水所化的药液而引起死亡。此药中毒的症状有代谢性酸中毒、中枢抑制、呼吸窘迫乃至喘息性呼吸、血压下降、肾损害、痫癎发作和颅内出血等。Kimura ET 等(Toxicol Appl Pharmacol 18:60,1971)报道,给大鼠含0.9%苯甲醇的生理盐水,单剂量静注,LD_(50)为305～450mg/kg。
Benzyl alcohol has a fatal risk for premature neonates. According to a letter from the FDA to the hospital pharmacist on May 28, 1982, a total of 16 newborns (weighing less than 2,500 grams) were vasoconstrictly irrigated with 0.9% benzyl alcohol in saline or Received by the use of benzyl alcohol-containing bacteria in the water for injection of liquid medicine and cause death. Symptoms of this drug poisoning metabolic acidosis, central suppression, respiratory distress and even breathing breath, blood pressure, kidney damage, epileptic seizures and intracranial hemorrhage and so on. Kimura ET et al. (Toxicol Appl Pharmacol 18: 60, 1971) reported that 0.9% benzyl alcohol in rats was given a single intravenous infusion of LD50 50 to 305-450 mg / kg.