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目的:探讨地高辛血浓度>2.0ng·ml-1的原因。方法:对地高辛血浓度>2.0ng·ml-1的51例患者病历进行分析。结果:病人年龄在50～93(76±11.0)岁,平均血药浓度为(2.89±0.89)ng·ml-1。致地高辛血浓度>2.0ng·ml-1的主要原因有:患者高龄、肾功能不全、不规则用药等等。大多数病人同时伴有中毒症状,少数病人(17.65%)无中毒症状。结论:监测地高辛血药浓度非常必要。对地高辛血浓度>2.0ng·ml-1的患者,还须根据临床症状及体征区别对待。
Objective: To investigate the causes of digoxin blood concentration> 2.0ng ml-1. Methods: The medical records of 51 patients with digoxin concentration> 2.0 ng · ml-1 were analyzed. Results: The patient’s age ranged from 50 to 93 years (76 ± 11.0) years. The mean plasma concentration was (2.89 ± 0.89) ng · ml-1. To digoxin blood concentration> 2.0ng ml-1 of the main reasons are: elderly patients, renal insufficiency, irregular medication and so on. Most patients accompanied by symptoms of poisoning, a small number of patients (17.65%) without symptoms of poisoning. Conclusion: It is very necessary to monitor the plasma concentration of digoxin. Patients with digoxin blood concentration> 2.0ng ml-1 should also be treated according to clinical symptoms and signs.