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目的探讨苦参素胶囊联合还原型谷胱甘肽治疗酒精性肝硬化的临床疗效。方法选取2012年1月~2014年4月我科收治的70例酒精性肝硬化患者作为研究对象,随机分为2组,各35例。对照组组给予常规治疗,观察组在对照的基础上给予苦参素胶囊联合还原型谷胱甘肽治疗,比较两组患者临床疗效及肝功能指标。结果观察组的治疗有效率为97.1%,明显高于对照组的77.1%的总有效率(P<0.05)。与对照组相比,观察组治疗后肝功能指标ALT、AST、GGT水平显著降低(P均<0.05)。结论苦参素胶囊联合还原型谷胱甘肽治疗酒精性肝硬化疗效可靠,能够显著提高临床疗效,并明显改善肝功能,临床上值得进一步研究。
Objective To investigate the clinical efficacy of oxymatrine capsules combined with reduced glutathione in the treatment of alcoholic liver cirrhosis. Methods Seventy patients with alcoholic liver cirrhosis admitted from January 2012 to April 2014 in our department were randomly divided into two groups of 35 patients. The control group was given routine treatment. The observation group was treated with matrine capsule combined with reduced glutathione on the basis of the control. The clinical curative effect and liver function index were compared between the two groups. Results The effective rate of treatment in the observation group was 97.1%, which was significantly higher than that of the control group (77.1%) (P <0.05). Compared with the control group, the liver function indexes ALT, AST and GGT in observation group decreased significantly (all P <0.05). Conclusion Oxymatrine capsules combined with reduced glutathione for the treatment of alcoholic liver cirrhosis is reliable, can significantly improve the clinical efficacy, and significantly improve liver function, it is worth further study clinically.