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对肺癌患者血清层粘连蛋白（ＬＮ）、透明质酸（ＨＡ）、白细胞介素－８（ＩＬ－８）含量进行测定，发现肺癌患者血清ＬＮ、ＨＡ及ｌＬ－８水平均较正常人显著升高；血清ＬＮ、ＨＡ及ＩＬ－８水平随肺癌浸润转移程度的加重而升高。小细胞肺癌患者血清ＬＮ、ＨＡ水平较非小细胞肺癌亦显著增高；化疗可使小细胞肺癌患者血清ＬＮ、ＨＡ明显降低。提示ＬＮ和ＨＡ水平与肺癌浸润转移密切相关，血清ＩＬ－８水平增高是机体抗肿瘤免疫反应之一。
The serum levels of laminin (LN), hyaluronic acid (HA), and interleukin-8 (IL-8) in lung cancer patients were measured. It was found that the serum levels of LN, HA, and lL-8 in patients with lung cancer were significantly higher than those in normal subjects. High; serum LN, HA and IL-8 levels increase with the degree of invasion and metastasis of lung cancer. The serum levels of LN and HA in patients with small cell lung cancer were also significantly higher than those in non-small cell lung cancer. Chemotherapy can significantly reduce serum LN and HA in patients with small cell lung cancer. It is suggested that the levels of LN and HA are closely related to the invasion and metastasis of lung cancer. The increase of serum IL-8 level is one of the body’s anti-tumor immune responses.