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目的观察炔雌醇环丙孕酮辅助治疗多囊卵巢综合征的临床效果,提高临床治疗水平。方法选取我院2007年1月~2009年12月收治的78例多囊卵巢综合征患者随机分为观察组(炔雌醇环丙孕酮辅助治疗组)和对照组(常规治疗组)各39例,比较两组患者的治疗效果。结果 (1)观察组与对照组治疗前后血清促卵泡素(FSH)、黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2)水平均有明显变化(P<0.05),其中FSH、LH、PRL观察组较对照组变化明显(P<0.05),具有统计学意义。(2)经过4个疗程后,观察组妊娠23例,妊娠率为58.9%;对照组妊娠14例,妊娠率为35.9%。两组比较差异显著(P<0.01),具有统计学意义。(3)观察组出现恶心2例,头晕1例,对照组出现面色潮红1例,头晕1例。结论炔雌醇环丙孕酮辅助治疗多囊卵巢综合征可明显改善性激素水平、提高妊娠率,服用过程中不良反应未见明显增加,值得临床推广使用。
Objective To observe the clinical effect of ethinylestradiol and cyproterone in adjuvant treatment of polycystic ovary syndrome and to improve the level of clinical treatment. Methods A total of 78 patients with PCOS who were admitted to our hospital from January 2007 to December 2009 were randomly divided into observation group (ethinyl estradiol cyproterone adjuvant therapy group) and control group (conventional therapy group) Cases, the treatment effect of two groups were compared. Results The levels of FSH, LH, PRL and E2 before and after treatment in observation group and control group all showed significant changes (P <0.05), among which FSH, LH, PRL observation group than the control group changed significantly (P <0.05), with statistical significance. (2) After 4 courses of treatment, the observation group had 23 cases of pregnancy with a pregnancy rate of 58.9%. In the control group, 14 cases were pregnant with a pregnancy rate of 35.9%. The difference between the two groups was significant (P <0.01), with statistical significance. (3) The observation group showed nausea in 2 cases and dizziness in 1 case. The control group showed flushing in 1 case and dizziness in 1 case. Conclusions Ethinylestradiol and cyproterone adjuvant treatment of polycystic ovary syndrome can significantly improve the level of sex hormones, improve pregnancy rate, taking no significant increase in adverse reactions during treatment, worthy of clinical promotion and use.