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2例双侧多囊肾并感染、慢性肾功能不全患者,治疗前无精神症状,静滴头孢唑啉每日4克后第3天出现症状:思维中断、幻觉、妄想和定向不能等(其中1例咬舌自杀2次)。出现精神症状与肾功能不全患者应用大剂量青霉素时出现的反应相似,似与剂量偏大有关。临床应警惕肾功能不全时头孢唑啉可致精神症状,故应小剂量应用或不用。治疗:对症治疗、
2 cases of bilateral polycystic kidney disease and infection, patients with chronic renal insufficiency, no psychiatric symptoms before treatment, intravenous cefazolin 4 grams daily 4 days after the onset of symptoms on the 3rd day: thinking interruption, hallucinations, delusions and orientation can not wait 1 case of biting tongue suicide 2 times). The emergence of psychiatric symptoms and renal insufficiency in patients with high doses of penicillin reaction appears similar, it seems that the dose is too large. Clinical should be wary of cefazolin can cause mental symptoms when renal insufficiency, it should be used in small doses or not. Treatment: symptomatic treatment,