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目的:比较吲哚菁绿和亚甲蓝在乳腺癌前哨淋巴结活检中的临床疗效。方法:选取我院2014年3月至2016年3月期间收治的240例乳腺癌患者,随机分为荧光组(n=120)及染色组(n=120),其中以吲哚菁绿作为示踪剂为荧光组,以亚甲蓝作为示踪剂为染色组,两组患者行前哨淋巴结活检结术后,行I、II水平腋窝淋巴清扫,比较术后两种示踪剂检出率、假阴性率及前哨淋巴结(SLN)检出个数,比较S型与M型淋巴引流的患者比例差异。结果:荧光组前哨淋巴结检出率为99.7%(116/120),染色组为93.3%(112/120),与染色组相比,荧光组检出率提高,组间比较数据具有统计学意义(P<0.05),荧光组假阴性率为5.2%,染色组假阴性率为8.4%,两组平均检出前哨淋巴结数量分别为荧光组(4.4±1.5)枚,染色组(4.2±1.6)枚,组间数据无统计学意义(P>0.05)。结论:吲哚菁绿检出率高于染料法,更适合作为前哨淋巴结活检术示踪剂。
Objective: To compare the clinical efficacy of indocyanine green and methylene blue in sentinel lymph node biopsy of breast cancer. Methods: A total of 240 breast cancer patients who were treated in our hospital from March 2014 to March 2016 were randomly divided into fluorescent group (n = 120) and staining group (n = 120), of which indocyanine green The tracer was fluorescent group and methylene blue was used as the tracer for the staining group. Two groups of patients underwent sentinel lymph node biopsy, I and II axillary lymph node dissection, the detection rate of two tracer, False negative rate and the number of sentinel lymph nodes (SLN) were detected in patients with S-type and M lymphatic drainage compared the proportion of patients. Results: The detection rate of sentinel lymph node was 99.7% (116/120) in fluorescence group and 93.3% (112/120) in staining group. The detection rate of fluorescence group increased compared with that of staining group, and there was statistical significance between the two groups (P <0.05). The false negative rate was 5.2% in fluorescence group and 8.4% in staining group. The average number of sentinel lymph nodes was 4.4 ± 1.5 in staining group and 4.2 ± 1.6 in staining group, Pieces, the data between groups was not statistically significant (P> 0.05). Conclusion: The detection rate of indocyanine green is higher than that of dye method, and it is more suitable as a tracer for sentinel lymph node biopsy.