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对隐匿性乙型肝炎病毒(乙肝病毒)感染的发生机制和检测方法进行综述,显示:乙肝病毒复制水平较低、病毒变异导致现有乙肝病毒表面抗原(HBsAg)试剂难以检出以及外周血单核细乙肝病毒感染是隐匿性乙肝病毒感染发生的重要原因,宿主因素以及丙肝病毒感染、血吸虫感染和长期饮酒等也与其发生有关。目前隐匿性乙肝病毒感染的检测方法和判断标准尚不一致。急需统一隐匿性乙肝病毒感染的检测方法和判断标准,并对其发生的分子机制及不同分子模式的发生频率开展进一步研究。
The pathogenesis and detection of occult Hepatitis B virus (HBV) infection are reviewed. The results show that HBV replication level is low, virus mutation leads to the difficulty of detection of the existing HBsAg reagent and peripheral blood mononucleosis Nucleated fine hepatitis B virus infection is an important cause of occult hepatitis B virus infection, host factors and hepatitis C virus infection, schistosomiasis and long-term drinking are also related to its occurrence. The current occult hepatitis B virus detection methods and criteria are not consistent. There is an urgent need to unify the detection methods and criteria for the detection of occult hepatitis B virus infection and further study on the molecular mechanisms and frequency of occurrence of different molecular patterns.