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目的对恶性肿瘤合并糖尿病患者的化疗经验进行总结。方法对46例合并糖尿病的恶性肿瘤患者进行EP、NP、TP、GP、FOLFOX、CHOP等方案的化疗,化疗中位周期数4个,在化疗前、中、后进行血糖干预和治疗。结果 39例完成预计的化疗周期数,4例化疗期间出现血糖升高、尿酮体阳性,3例因骨髓抑制及消化道反应重停止化疗。结论有效控制血糖情况下,恶性肿瘤合并糖尿病患者的化疗是安全的。
Objective To summarize the experience of chemotherapy in malignant tumor with diabetes mellitus. Methods 46 cases of malignant tumor patients with diabetes mellitus were treated with EP, NP, TP, GP, FOLFOX and CHOP chemotherapy. The median number of cycles of chemotherapy was 4, and the blood glucose intervention and treatment were performed before, during and after chemotherapy. Results 39 cases completed the expected number of chemotherapy cycles, 4 cases of chemotherapy during the rise in blood sugar, urine ketone body was positive, 3 cases of bone marrow suppression and gastrointestinal reactions due to heavy chemotherapy. Conclusion The chemotherapy of malignant tumor complicated with diabetes mellitus is safe when the blood sugar is effectively controlled.