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本文对73例原发性肾病和53例急性肾炎患儿进行了HBsAg的检测,其阴性率分别为17.8％和18.8％,与本地区正常人群HBsAg普查结果相比,明显升高,从而怀疑乙肝病毒有否可能为原发性肾小球疾病的病因之一,(其通过免疫反应而引起乙型肝炎相关性肾炎)。临床分析表明:肾炎者以内眼血尿为主要临床表现,可伴有肝大和不同程度的肝功能损害,病程迁延,常反复发作;表现为肾病者,则多属于肾炎性肾病,对激素治疗不敏感。作者建议今后对HBsAg持续阳性的患儿应反复检查尿常规和肾功能,对肾病,肾炎患者应常规查HBsAg,并争取多开展肝、肾组织的活检,以进一步揭示两者之间的联系。
In this paper, 73 cases of primary nephropathy and 53 cases of acute nephritis in children with HBsAg detection, the negative rates were 17.8% and 18.8%, respectively, with the normal population in the region compared with the results of HBsAg was significantly elevated, and thus suspected hepatitis B Is it possible that the virus is one of the causes of primary glomerular disease, which causes hepatitis B-associated nephritis through an immune response. Clinical analysis shows that: nephritis with endogenous hematuria as the main clinical manifestations may be associated with varying degrees of liver damage and liver function, duration of the disease, often repeated attacks; manifested as kidney disease, are mostly nephritis, nephropathy is not sensitive to hormone therapy . The authors suggest that children with persistent HBsAg should be examined urinary routine and renal function in the future, HBsAg should be routinely checked in patients with nephropathy and nephritis, and more biopsies of liver and kidney should be made to further reveal the relationship between the two.