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目的探讨应用功能显像确定食管癌生物靶区的可行性。方法 20例初治食管癌进行BIMRT计划设计。定义2个靶区:GTV-HL91为需要加量照射的原发灶乏氧阳性靶区,给予69 Gy(2.3 Gy×30次);GTV-T和GTV-N给予66 Gy(2.2 Gy×30次)的剂量。结果所有患者均在6周内完成治疗计划,治疗中仅1例发生3级放射性气管炎,3级以上急性放射性食管炎仅2例,占100%(2/20)。近期疗效评价CR率85%(17/20),PR率15%(3/20),CR+PR率为100%。结论乏氧功能显像结果指导食管癌食管癌生物靶区调强放疗近期治疗效果满意,急性放射反应可耐受,具有一定临床应用价值。
Objective To explore the feasibility of functional imaging in the determination of biological target area of esophageal cancer. Methods Twenty patients with newly diagnosed esophageal cancer underwent BIMRT program design. Two target regions were defined: GTV-HL91 (69 Gy, 2.3 Gy × 30 times) for the hypoxia-positive target of the primary tumor in need of additional irradiation, 66 Gy (2.2 Gy × 30 GTV-T and GTV- Times) dose. Results All patients completed the treatment plan within 6 weeks. Only 1 patient had grade 3 radiation bronchitis and 2 patients had grade 3 or above acute radiation esophagitis, accounting for 100% (2/20). The recent CR rate was 85% (17/20), PR 15% (3/20) and CR + PR 100%. Conclusions The results of hypoxic imaging can guide the esophageal cancer esophageal cancer target intensifying radiotherapy in the short term. The therapeutic effect is satisfactory and the acute radiation reaction can be tolerated, which has a certain clinical value.