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槐定碱(Sophoridine)是从豆科植物苦豆子(Sepheraalopecuroides)中提出的生物碱。本文的几种动物心律失常模型,证明它有抗心律失常的作用。(一)抗哇巴因诱发的豚鼠心律失常:槐定碱10mg/kg静注,可增加哇巴因静脉内注射,诱发早搏所需要的剂量和致死量。(二)拮抗氯化钙诱发的大鼠心律失常:槐定碱10mg/kg静注,可降低大鼠静脉注射13mg/kg CCl_2所引起的室颤发生率(P<0.05)和死亡率(P
Sophoridine is an alkaloid proposed from the plant of the legume Sophora alopecuroides. Several animal arrhythmia models in this article have demonstrated that it has antiarrhythmic effects. (A) Anti-ouabain-induced arrhythmias in guinea pigs: Sophoridine 10 mg/kg intravenously increases the dosage and lethal dose required for ouabain intravenous injection to induce premature beats. (B) antagonistic calcium chloride induced rat arrhythmias: sophoridine 10mg/kg intravenously, can reduce the incidence of ventricular fibrillation (P <0.05) and mortality caused by intravenous injection of 13mg/kg CCl_2 in rats (P