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目的探讨脑缺血预适应(BIP)对急性脑梗死(ACI)的神经保护作用。方法收集2005年10月至2007年4月潮州市中心医院门诊及住院收治短暂性脑缺血发作(TIA)后发生 ACI 患者60例,其中30例 TIA 时长≤20 min 为 A1组,30例 TIA 时长>20 min且≤60 min 为 A2组;同期随机抽取 ACI 前无 TIA 的病例30例为 B组(对照组)。ACI 病例观察梗死病灶大小、神经功能评分、病变程度及疗效等指标。结果 TIA 后 ACI,A1组梗死病灶较小,神经功能评分较低,重度病例少,基本痊愈率、显效率及总有效率较高,优于对照组(P<0.01),而A2组差别则无显著性(P>0.05)。结论持续适当的 BIP 对其后发生的 ACI 能产生神经保护作用。
Objective To investigate the neuroprotective effect of ischemic preconditioning (BIP) on acute cerebral infarction (ACI). Methods Sixty ACI patients were collected from outpatient department and hospitalized in Teochew Central Hospital from October 2005 to April 2007, of which 30 cases had TIA for duration of ≤20 minutes as A1 group and 30 cases for TIA Duration> 20 min and ≤60 min were in group A2; 30 patients without TIA before random ACI were in group B (control group). ACI cases observed infarct size, neurological score, degree of lesion and efficacy and other indicators. Results After TIA, the infarct size of ACI and A1 group was lower, the score of neurological function was lower, the number of severe cases was less, the basic recovery rate, effective rate and total effective rate were higher than those in control group (P <0.01) No significant (P> 0.05). CONCLUSIONS: Sustained and appropriate BIP has neuroprotective effects on the ACI that occurs thereafter.