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正确预测重症肝坏死(FHN)患者能否存活,对决定哪些患者需作肝移植至关重要。近年文献报道从FHN患者测得其血清维生素D-结合蛋白(G_C)值低,本文报道测定结果并讨论与其预后的关系。G_C是一种分子量较大的血清蛋白,半衰期短,由肝脏合成,是维生素D_3代谢物的主要生理载体。在血清中其正常值为280～560mg/L。G_C能与生理性细胞转变或病理性组织坏死时释出的肌纤蛋白(actin)结合成复合型G_C,在健康者仅一小部分G_C在血液中形成含有G_C-actin高分子复合型蛋白;在FHN患者此种蛋白显著升高、而G_C的总值则相应下降。
Correctly predicting the survival of patients with severe hepatic necrosis (FHN) is crucial for determining which patients need liver transplantation. In recent years, it has been reported in the literature that the serum vitamin D-binding protein (G_C) is low in patients with FHN. This paper reports the results and discusses the relationship with the prognosis. G_C is a high molecular weight serum protein with short half-life and is synthesized by the liver. It is the main physiological carrier of vitamin D 3 metabolites. Its normal serum level is 280 ~ 560mg / L. G_C with physiological cells or pathological tissue necrosis of the actin release combined with complex G_C, only a small part of healthy G_C in the blood to form a complex containing G_C-actin protein; In FHN patients with this protein was significantly increased, while the total value of G_C decreased accordingly.