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自七十年代以来,在世界范围内,在同人体健康关系密切的各种化学物的安全性评价方面做了大量工作。由于动物致癌试验费时耗资甚大,人们对检测化学物致突变性的“短周期试验”技术特别感兴趣,至今已经发明了一百多种,常用的有几十种。其中使用最多的是Ames试验,可在1～2周内得出结果。但研究资料说明,该试验仍有约10％的假阳性率和10％的假阴性率。其它试验方法也大抵如此。因此就需要同时用几种
Since the 1970s, a great deal of work has been done around the world in the safety evaluation of various chemicals that are closely related to human health. Due to the time-consuming and costly animal carcinogen test, people are particularly interested in the “short-cycle test” technology for detecting the mutagenicity of chemicals. Up to now, over 100 ones have been invented, and dozens are commonly used. One of the most used is the Ames test, which gives results in 1 to 2 weeks. However, research data shows that the trial still has about 10% false positive rate and 10% false negative rate. Other test methods are probably the case. So you need to use several at the same time